Ontology highlight
ABSTRACT:
SUBMITTER: Todi SV
PROVIDER: S-EPMC2646149 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Todi Sokol V SV Winborn Brett J BJ Scaglione K Matthew KM Blount Jessica R JR Travis Sue M SM Paulson Henry L HL
The EMBO journal 20090115 4
Deubiquitinating enzymes (DUBs) control the ubiquitination status of proteins in various cellular pathways. Regulation of the activity of DUBs, which is critically important to cellular homoeostasis, can be achieved at the level of gene expression, protein complex formation, or degradation. Here, we report that ubiquitination also directly regulates the activity of a DUB, ataxin-3, a polyglutamine disease protein implicated in protein quality control pathways. Ubiquitination enhances ubiquitin ( ...[more]