Ontology highlight
ABSTRACT:
SUBMITTER: Yodh JG
PROVIDER: S-EPMC2646154 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Yodh Jaya G JG Stevens Benjamin C BC Kanagaraj Radhakrishnan R Janscak Pavel P Ha Taekjip T
The EMBO journal 20090122 4
Bloom syndrome (BS) is a rare genetic disorder characterized by genomic instability and a high predisposition to cancer. The gene defective in BS, BLM, encodes a member of the RecQ family of 3'-5' DNA helicases, and is proposed to function in recombinational repair during DNA replication. Here, we have utilized single-molecule fluorescence resonance energy transfer microscopy to examine the behaviour of BLM on forked DNA substrates. Strikingly, BLM unwound individual DNA molecules in a repetitiv ...[more]