Polymorphic secreted kinases are key virulence factors in toxoplasmosis.
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ABSTRACT:
SUBMITTER: Saeij JP
PROVIDER: S-EPMC2646183 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
Polymorphic secreted kinases are key virulence factors in toxoplasmosis.
Saeij J P J JP Boyle J P JP Coller S S Taylor S S Sibley L D LD Brooke-Powell E T ET Ajioka J W JW Boothroyd J C JC
Science (New York, N.Y.) 20061201 5806
The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the responsible genes, we mapped virulence in F(1) progeny derived from crosses between type II and type III strains, which we introduced into mice. Five virulence (VIR) loci were thus identified, and for two of these, genetic complementation showed that a predicted protein kinase (ROP18 and ROP16, respectively ...[more]
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