Ontology highlight
ABSTRACT:
SUBMITTER: Attanasio C
PROVIDER: S-EPMC2646272 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Attanasio Catia C Reymond Alexandre A Humbert Richard R Lyle Robert R Kuehn Michael S MS Neph Shane S Sabo Peter J PJ Goldy Jeff J Weaver Molly M Haydock Andrew A Lee Kristin K Dorschner Michael M Dermitzakis Emmanouil T ET Antonarakis Stylianos E SE Stamatoyannopoulos John A JA
Genome biology 20081202 12
<h4>Background</h4>Conserved non-coding sequences in the human genome are approximately tenfold more abundant than known genes, and have been hypothesized to mark the locations of cis-regulatory elements. However, the global contribution of conserved non-coding sequences to the transcriptional regulation of human genes is currently unknown. Deeply conserved elements shared between humans and teleost fish predominantly flank genes active during morphogenesis and are enriched for positive transcri ...[more]