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Incomplete coverage of candidate genes: a poorly considered bias.

ABSTRACT: Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed.

SUBMITTER: Drago A

PROVIDER: S-EPMC2647155 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature

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Incomplete coverage of candidate genes: a poorly considered bias.

Drago Antonio A De Ronchi Diana D Serretti Alessandro A

Current genomics 20071101 7

Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a ...[more]

PMID: 19412419

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