Ontology highlight
ABSTRACT:
SUBMITTER: Shibata N
PROVIDER: S-EPMC2647723 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Shibata Nobuto N Kawarai Toshitaka T Meng Yan Y Lee Joseph H JH Lee Hye-Seung HS Wakutani Yosuke Y Shibata Eri E Pathan Nazia N Bi Andrew A Sato Christine C Sorbi Sandro S Bruni Amalia C AC Duara Ranjan R Mayeux Richard R Farrer Lindsay A LA George-Hyslop Peter St PS Rogaeva Ekaterina E
Neurobiology of aging 20060707 7
The plasmin system is involved in the degradation of Abeta peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD). In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system. Among the four polymorphisms in the PLAT, PAI-1 and PLI genes showing nominally significant evidence for an association with AD (allele p-value=0.01-0.00003) the strongest association was detected ...[more]