Ontology highlight
ABSTRACT:
SUBMITTER: Reddy BY
PROVIDER: S-EPMC2647978 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Reddy Bobby Y BY Greco Steven J SJ Patel Prem S PS Trzaska Katarzyna A KA Rameshwar Pranela P
Proceedings of the National Academy of Sciences of the United States of America 20090225 11
Breast cancer remains the most prevalent cancer among women in the United States. Substance P, a peptide derived from the TAC1 gene, mediates oncogenic properties in breast and other cancers. TAC1 expression facilitates the entry of breast cancer cells into bone marrow. The transcriptional repressor element 1-silencing transcription factor (REST) has been implicated in both oncogenic and tumor-suppressor functions. REST binds to the 5' untranslated region of the TAC1 promoter and suppresses its ...[more]