Block liposomes from curvature-stabilizing lipids: connected nanotubes, -rods, or -spheres.
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ABSTRACT:
SUBMITTER: Zidovska A
PROVIDER: S-EPMC2647992 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Block liposomes from curvature-stabilizing lipids: connected nanotubes, -rods, or -spheres.
Zidovska Alexandra A Ewert Kai K KK Quispe Joel J Carragher Bridget B Potter Clinton S CS Safinya Cyrus R CR
Langmuir : the ACS journal of surfaces and colloids 20090301 5
We report on the discovery of block liposomes, a new class of chain-melted (liquid) vesicles, with membranes comprised of mixtures of the membrane-curvature-stabilizing multivalent lipid MVLBG2 of colossal charge +16 e and neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In a narrow MVLBG2 composition range (8-10 mol%), cryo-TEM revealed block liposomes consisting of distinctly shaped, yet connected, nanoscale spheres, pears, tubes, or rods. Unlike typical liposome systems, where sp ...[more]
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