Ancestry-environment interactions and asthma risk among Puerto Ricans.

ABSTRACT:

Background

Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, no such relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry.

Methods

We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median fami

SUBMITTER: Choudhry S 

PROVIDER: S-EPMC2648109 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature