Ontology highlight
ABSTRACT:
SUBMITTER: Ramanan S
PROVIDER: S-EPMC2648135 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Free radical biology & medicine 20080917 12
Whole-brain irradiation (WBI) can lead to cognitive impairment several months to years after irradiation. Studies on rodents have shown a rapid and sustained increase in activated microglia (brain macrophages) following brain irradiation, contributing to a chronic inflammatory response and a corresponding decrease in hippocampal neurogenesis. Thus, alleviating microglial activation following radiation represents a key strategy to minimize WBI-induced morbidity. We hypothesized that pretreatment ...[more]