Dataset Information

Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study.

ABSTRACT: There have been many functional imaging studies that have investigated the neural correlates of speech perception by contrasting neural responses to speech and "speech-like" but unintelligible control stimuli. A potential drawback of this approach is that intelligibility is necessarily conflated with a change in the acoustic parameters of the stimuli. The approach we have adopted is to take advantage of the mismatch response elicited by an oddball paradigm to probe neural responses in temporal lobe structures to a parametrically varied set of deviants in order to identify brain regions involved in vowel processing. Thirteen normal subjects were scanned using a functional magnetic resonance imaging (fMRI) paradigm while they listened to continuous trains of auditory stimuli. Three classes of stimuli were used: 'vowel deviants' and two classes of control stimuli: one acoustically similar ('single formants') and the other distant (tones). The acoustic differences between the standard and deviants in both the vowel and single-formant classes were designed to match each other closely. The results revealed an effect of vowel deviance in the left anterior superior temporal gyrus (aSTG). This was most significant when comparing all vowel deviants to standards, irrespective of their psychoacoustic or physical deviance. We also identified a correlation between perceptual discrimination and deviant-related activity in the dominant superior temporal sulcus (STS), although this effect was not stimulus specific. The responses to vowel deviants were in brain regions implicated in the processing of intelligible or meaningful speech, part of the so-called auditory "what" processing stream. Neural components of this pathway would be expected to respond to sudden, perhaps unexpected changes in speech signal that result in a change to narrative meaning.

SUBMITTER: Leff AP

PROVIDER: S-EPMC2648503 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study.

Leff Alexander P AP Iverson Paul P Schofield Thomas M TM Kilner James M JM Crinion Jennifer T JT Friston Karl J KJ Price Cathy J CJ

Cortex; a journal devoted to the study of the nervous system and behavior 20080207 4

There have been many functional imaging studies that have investigated the neural correlates of speech perception by contrasting neural responses to speech and "speech-like" but unintelligible control stimuli. A potential drawback of this approach is that intelligibility is necessarily conflated with a change in the acoustic parameters of the stimuli. The approach we have adopted is to take advantage of the mismatch response elicited by an oddball paradigm to probe neural responses in temporal l ...[more]

PMID: 19231480

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Project description:Experimentalists studying multisensory integration compare neural responses to multisensory stimuli with responses to the component modalities presented in isolation. This procedure is problematic for multisensory speech perception since audiovisual speech and auditory-only speech are easily intelligible but visual-only speech is not. To overcome this confound, we developed intracranial encephalography (iEEG) deconvolution. Individual stimuli always contained both auditory and visual speech, but jittering the onset asynchrony between modalities allowed for the time course of the unisensory responses and the interaction between them to be independently estimated. We applied this procedure to electrodes implanted in human epilepsy patients (both male and female) over the posterior superior temporal gyrus (pSTG), a brain area known to be important for speech perception. iEEG deconvolution revealed sustained positive responses to visual-only speech and larger, phasic responses to auditory-only speech. Confirming results from scalp EEG, responses to audiovisual speech were weaker than responses to auditory-only speech, demonstrating a subadditive multisensory neural computation. Leveraging the spatial resolution of iEEG, we extended these results to show that subadditivity is most pronounced in more posterior aspects of the pSTG. Across electrodes, subadditivity correlated with visual responsiveness, supporting a model in which visual speech enhances the efficiency of auditory speech processing in pSTG. The ability to separate neural processes may make iEEG deconvolution useful for studying a variety of complex cognitive and perceptual tasks.SIGNIFICANCE STATEMENT Understanding speech is one of the most important human abilities. Speech perception uses information from both the auditory and visual modalities. It has been difficult to study neural responses to visual speech because visual-only speech is difficult or impossible to comprehend, unlike auditory-only and audiovisual speech. We used intracranial encephalography deconvolution to overcome this obstacle. We found that visual speech evokes a positive response in the human posterior superior temporal gyrus, enhancing the efficiency of auditory speech processing.

Dataset Information

Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study.

Publications

Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study.

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