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Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China.

ABSTRACT: In the present study, a genotype 4 HEV strain was identified in the fecal specimen from a seven months old infant with no symptom of hepatitis in Shanghai Children's hospital. The full capsid protein gene (ORF2) sequence of this strain was determined by RT-PCR method. Sequence analysis based on the full ORF2 sequence indicated that this HEV strain shared the highest sequence identity (97.6%) with another human HEV strain isolated from a Japanese patient who was infected by genotype 4 HEV during traveling in Shanghai. Phylogenetic analysis showed that this genotype 4 HEV was phylogenetically far from the genotype 4 HEV strain that was commonly prevalent in Shanghai swine group, suggesting that this strain may not come from swine group and not involved in zoonotic transmission in this area.

SUBMITTER: Zhang W

PROVIDER: S-EPMC2649060 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China.

Zhang Wen W Yang Shixing S Shen Quan Q Liu Junfeng J Shan Tongling T Huang Fen F Ning Huibo H Kang Yanjun Y Yang Zhibiao Z Cui Li L Zhu Jianguo J Hua Xiuguo X

Virology journal 20090216

In the present study, a genotype 4 HEV strain was identified in the fecal specimen from a seven months old infant with no symptom of hepatitis in Shanghai Children's hospital. The full capsid protein gene (ORF2) sequence of this strain was determined by RT-PCR method. Sequence analysis based on the full ORF2 sequence indicated that this HEV strain shared the highest sequence identity (97.6%) with another human HEV strain isolated from a Japanese patient who was infected by genotype 4 HEV during ...[more]

PMID: 19220877

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