Ontology highlight
ABSTRACT:
SUBMITTER: Arnold T
PROVIDER: S-EPMC2649078 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Arnold Thomas T Zeth Kornelius K Linke Dirk D
The Journal of biological chemistry 20081204 10
Colicins are plasmid-encoded toxic proteins produced by Escherichia coli strains to kill other E. coli strains that lack the corresponding immunity protein. Colicins intrude into the host cell by exploiting existing transport, diffusion, or efflux systems. We have traced the way colicin S4 takes to execute its function and show that it interacts specifically with OmpW, OmpF, and the Tol system before it inserts its pore-forming domain into the cytoplasmic membrane. The common structural architec ...[more]