Ontology highlight
ABSTRACT:
SUBMITTER: Edelbrock MA
PROVIDER: S-EPMC2649689 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Mutation research 20081224 1-2
DNA mismatch repair (MMR) within human cells is hypothesized to occur primarily at the replication fork. However, experimental models measuring MMR activity at specific phases of the cell cycle and during genomic DNA synthesis are lacking. We have investigated MMR activity within the nuclear environment of HeLa cells after enriching for G1, S and G2/M phase of the cell cycle by centrifugal elutriation. This approach preserves physiologically normal MMR activity in cell populations subdivided int ...[more]