Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2649781 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Liu Juewen J Stace-Naughton Alison A Jiang Xingmao X Brinker C Jeffrey CJ
Journal of the American Chemical Society 20090201 4
Mixing liposomes with hydrophilic particles induces fusion of the liposome onto the particle surface. Such supported bilayers have been studied extensively as models of the cell membrane, while their applications in drug delivery have not been pursued. In this communication, we report liposome fusion on mesoporous particles as a synergistic means to simultaneously load and seal cargo within the porous core. We find fusion of a cationic lipid (DOTAP) on an anionic silica particle loads an anionic ...[more]