Ontology highlight
ABSTRACT:
SUBMITTER: Shrum CK
PROVIDER: S-EPMC2650318 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Shrum Cynthia K CK Defrancisco Daniel D Meffert Mollie K MK
Proceedings of the National Academy of Sciences of the United States of America 20090205 8
Translocation from the cytoplasm to the nucleus is required for the regulation of gene expression by transcription factors of the nuclear factor kappa B (NF-kappaB) family. The p65:p50 NF-kappaB heterodimer that predominates in many cell types can undergo stimulated movement, following degradation of the IkappaB inhibitor, as well as shuttling in the absence of stimulation with IkappaB bound. Disruption of the dynactin complex and knockdown of endogenous dynein were used to investigate the nucle ...[more]