Ontology highlight
ABSTRACT:
SUBMITTER: Iyaguchi D
PROVIDER: S-EPMC2650458 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Iyaguchi Daisuke D Yao Min M Tanaka Isao I Toyota Eiko E
Acta crystallographica. Section F, Structural biology and crystallization communications 20090226 Pt 3
Adenylate/uridylate-rich elements (AREs), which are found in the 3'-untranslated region (UTR) of many mRNAs, influence the stability of cytoplasmic mRNA. HuR (human antigen R) binds to AREs and regulates various genes. In order to reveal the RNA-recognition mechanism of HuR protein, an RNA-binding region of human HuR containing two N-terminal RNA-recognition motif domains bound to an 11-base RNA fragment has been crystallized. The crystals belonged to space group P2(1)2(1)2(1), with unit-cell pa ...[more]