Ontology highlight
ABSTRACT:
SUBMITTER: Wise-Draper TM
PROVIDER: S-EPMC2650744 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Wise-Draper Trisha M TM Mintz-Cole Rachael A RA Morris Teresa A TA Simpson David S DS Wikenheiser-Brokamp Kathryn A KA Currier Mark A MA Cripe Timothy P TP Grosveld Gerard C GC Wells Susanne I SI
Cancer research 20090217 5
High levels of expression of the human DEK gene have been correlated with numerous human malignancies. Intracellular DEK functions have been described in vitro and include DNA supercoiling, DNA replication, RNA splicing, and transcription. We have shown that DEK also suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft models. Such functions are likely to contribute to cancer, but direct evidence to i ...[more]