Ontology highlight
ABSTRACT:
SUBMITTER: Lund IV
PROVIDER: S-EPMC2651003 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lund Ingrid V IV Hu Yinghui Y Raol YogendraSinh H YH Benham Rebecca S RS Faris Ramona R Russek Shelley J SJ Brooks-Kayal Amy R AR
Science signaling 20081014 41
The gamma-aminobutyric acid (GABA) type A receptor (GABA(A)R) is the major inhibitory neurotransmitter receptor in the brain. Its multiple subunits show regional, developmental, and disease-related plasticity of expression; however, the regulatory networks controlling GABA(A)R subunit expression remain poorly understood. We report that the seizure-induced decrease in GABA(A)R alpha1 subunit expression associated with epilepsy is mediated by the Janus kinase (JAK)/signal transducer and activator ...[more]