Ontology highlight
ABSTRACT:
SUBMITTER: Praetor A
PROVIDER: S-EPMC2651011 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Praetor Asja A McBride Jacqueline M JM Chiu Henry H Rangell Linda L Cabote Lorena L Lee Wyne P WP Cupp James J Danilenko Dimitry M DM Fong Sherman S
Blood 20081224 9
Hematopoietic stem cells (HSCs) have the capacity to self-renew and continuously differentiate into all blood cell lineages throughout life. At each branching point during differentiation, interactions with the environment are key in the generation of daughter cells with distinct fates. Here, we examined the role of the cell adhesion molecule JAM-C, a protein known to mediate cellular polarity during spermatogenesis, in hematopoiesis. We show that murine JAM-C is highly expressed on HSCs in the ...[more]