Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation.
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ABSTRACT:
SUBMITTER: Bukrinsky A
PROVIDER: S-EPMC2651015 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation.
Bukrinsky Alex A Griffin Kevin J P KJ Zhao Yan Y Lin Shuo S Banerjee Utpal U
Blood 20090108 9
The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1-like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream of etsrp, scl, and spi-1/pu.1 in myeloid differentiation. Spi-1l is coexpressed in a subset of spi-1/pu.1 ...[more]
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