Ontology highlight
ABSTRACT:
SUBMITTER: Kastrup CJ
PROVIDER: S-EPMC2651025 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Kastrup Christian J CJ Boedicker James Q JQ Pomerantsev Andrei P AP Moayeri Mahtab M Bian Yao Y Pompano Rebecca R RR Kline Timothy R TR Sylvestre Patricia P Shen Feng F Leppla Stephen H SH Tang Wei-Jen WJ Ismagilov Rustem F RF
Nature chemical biology 20081201 12
Blood coagulation often accompanies bacterial infections and sepsis and is generally accepted as a consequence of immune responses. Though many bacterial species can directly activate individual coagulation factors, they have not been shown to directly initiate the coagulation cascade that precedes clot formation. Here we demonstrated, using microfluidics and surface patterning, that the spatial localization of bacteria substantially affects coagulation of human and mouse blood and plasma. Bacil ...[more]