Ontology highlight
ABSTRACT:
SUBMITTER: Huang YH
PROVIDER: S-EPMC2651300 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Huang Yu-Hung YH Bao Yunhua Y Peng Weidan W Goldberg Michael M Love Kevin K Bumcrot David A DA Cole Geoffrey G Langer Robert R Anderson Daniel G DG Sawicki Janet A JA
Proceedings of the National Academy of Sciences of the United States of America 20090210 9
Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. Previous in vitro studies have indicated that CLDN3 overexpression promotes the migration, invasion, and survival of ovarian cancer cells. Here, we investigated the efficacy of lipidoid-formulated CLDN3 siRNA in 3 different ovarian cancer models. Intratumoral injection of lipidoid/CLDN3 siRNA into OVCAR-3 xenografts resulted in dramatic silencing of CLDN3, significant reduction in cell proliferation, re ...[more]