Ontology highlight
ABSTRACT:
SUBMITTER: Smalley KS
PROVIDER: S-EPMC2651569 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Smalley Keiran S M KS Lioni Mercedes M Dalla Palma Maurizia M Xiao Min M Desai Brijal B Egyhazi Suzanne S Hansson Johan J Wu Hong H King Alastair J AJ Van Belle Patricia P Elder David E DE Flaherty Keith T KT Herlyn Meenhard M Nathanson Katherine L KL
Molecular cancer therapeutics 20080901 9
Recent studies have shown that there is a considerable heterogeneity in the response of melanoma cell lines to MEK and BRAF inhibitors. In the current study, we address whether dysregulation of cyclin-dependent kinase 4 (CDK4) and/or cyclin D1 contribute to the BRAF inhibitor resistance of melanoma cells. Mutational screening identified a panel of melanoma cell lines that harbored both a BRAF V600E mutation and a CDK4 mutation: K22Q (1205Lu), R24C (WM39, WM46, and SK-Mel-28), and R24L (WM902B). ...[more]