Structural insight into RNA hairpin folding intermediates.
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ABSTRACT:
SUBMITTER: Bowman GR
PROVIDER: S-EPMC2652247 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Structural insight into RNA hairpin folding intermediates.
Bowman Gregory R GR Huang Xuhui X Yao Yuan Y Sun Jian J Carlsson Gunnar G Guibas Leonidas J LJ Pande Vijay S VS
Journal of the American Chemical Society 20080701 30
Hairpins are a ubiquitous secondary structure motif in RNA molecules. Despite their simple structure, there is some debate over whether they fold in a two-state or multi-state manner. We have studied the folding of a small tetraloop hairpin using a serial version of replica exchange molecular dynamics on a distributed computing environment. On the basis of these simulations, we have identified a number of intermediates that are consistent with experimental results. We also find that folding is n ...[more]
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