Ontology highlight
ABSTRACT:
SUBMITTER: Alden-Danforth E
PROVIDER: S-EPMC2652256 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Alden-Danforth Ethan E Scerba Michael T MT Lectka Thomas T
Organic letters 20081014 21
The catalytic, enantioselective, [4 + 2] cycloaddition reaction of ortho-quinone methides with silyl ketene acetals is described. This mechanistically interesting reaction, initiated by a chiral cinchona alkaloid-derived ammonium fluoride "precatalyst" complex, affords a variety of alkyl- and aryl-substituted 3,4-dihydrocoumarin products in excellent yield and with good enantioselectivity. ...[more]