Structure of the capsular polysaccharide of pneumococcal serotype 11A reveals a novel acetylglycerol that is the structural basis for 11A subtypes.
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ABSTRACT:
SUBMITTER: Zartler ER
PROVIDER: S-EPMC2652282 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
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Structure of the capsular polysaccharide of pneumococcal serotype 11A reveals a novel acetylglycerol that is the structural basis for 11A subtypes.
Zartler Edward R ER Porambo Richard J RJ Anderson Carrie L CL Chen Lorenzo H LH Yu Jigui J Nahm Moon H MH
The Journal of biological chemistry 20081229 11
We have undertaken a structural assessment of Streptococcus pneumoniae 11A polysaccharide as well as two clinical isolates related to 11A. The clinical isolates were labeled 11Aalpha and 11Abeta. The result of our experiments is a revision to the old structure for S. pneumoniae 11A polysaccharide. The new structure differs from the old structure in both the primary connectivities and acetylation pattern. We also show that 11A contains an acetylglycerol-PO4 moiety, a substitution that is heretofo ...[more]
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