Ontology highlight
ABSTRACT:
SUBMITTER: Chen CS
PROVIDER: S-EPMC2652326 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Chen Connie S CS Nelson Celeste M CM Khauv Davitte D Bennett Simone S Radisky Evette S ES Hirai Yohei Y Bissell Mina J MJ Radisky Derek C DC
The Journal of biological chemistry 20090107 11
We have shown that branching morphogenesis of mammary ductal structures requires the action of the morphogen epimorphin/syntaxin-2. Epimorphin, originally identified as an extracellular molecule, is identical to syntaxin-2, an intracellular molecule that is a member of the extensively investigated syntaxin family of proteins that mediate vesicle trafficking. We show here that, although epimorphin/syntaxin-2 is highly homologous to syntaxin-1a, only epimorphin/syntaxin-2 can stimulate mammary bra ...[more]