Ontology highlight
ABSTRACT:
SUBMITTER: Li JY
PROVIDER: S-EPMC2652503 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Developmental cell 20090101 1
Developing organs require iron for a myriad of functions, but embryos deleted of the major adult transport proteins, transferrin or its receptor transferrin receptor1 (TfR1(-/-)), still initiate organogenesis, suggesting that non-transferrin pathways are important. To examine these pathways, we developed chimeras composed of fluorescence-tagged TfR1(-/-) cells and untagged wild-type cells. In the kidney, TfR1(-/-) cells populated capsule and stroma, mesenchyme and nephron, but were underrepresen ...[more]