Ontology highlight
ABSTRACT:
SUBMITTER: Nieman MT
PROVIDER: S-EPMC2652574 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Nieman M T MT Burke F F Warnock M M Zhou Y Y Sweigart J J Chen A A Ricketts D D Lucchesi B R BR Chen Z Z Di Cera E E Hilfinger J J Kim J S JS Mosberg H I HI Schmaier A H AH
Journal of thrombosis and haemostasis : JTH 20080225 5
<h4>Background</h4>Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin - RPPGF.<h4>Methods and results</h4>These peptides are direct thrombin inhibitors prolonging the thrombin clotting time, activated partial thromboplastin time, and prothrombin time at >or=0.78, 1.6, and 1.6 microm, respectively. They competitively inhibit alpha-thrombin-ind ...[more]