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A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions.

ABSTRACT: This paper introduces a chemical model of a beta-sheet that dimerizes through parallel beta-sheet interactions in CDCl(3) solution. The model consists of two C-terminally linked dipeptides connected to a molecular template. (1)H NMR studies establish the beta-sheet folding and dimerization of the model system. This system corroborates that linking two peptide strands and blocking one edge of the assembly creates soluble, easy-to-study systems that participate in the types of interactions that occur widely in peptide and protein aggregates.

SUBMITTER: Levin S

PROVIDER: S-EPMC2652689 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions.

Levin Sergiy S Nowick James S JS

Organic letters 20090201 4

This paper introduces a chemical model of a beta-sheet that dimerizes through parallel beta-sheet interactions in CDCl(3) solution. The model consists of two C-terminally linked dipeptides connected to a molecular template. (1)H NMR studies establish the beta-sheet folding and dimerization of the model system. This system corroborates that linking two peptide strands and blocking one edge of the assembly creates soluble, easy-to-study systems that participate in the types of interactions that oc ...[more]

PMID: 19173616

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