Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC2653189 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
PloS one 20090310 3
Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which consists of three sites--the pY-residue binding site, the +3 residue-binding site and a hydrophobic binding site, which served as a selectivity fi ...[more]