Evolution of the arginase fold and functional diversity.
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ABSTRACT:
SUBMITTER: Dowling DP
PROVIDER: S-EPMC2653620 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Evolution of the arginase fold and functional diversity.
Dowling D P DP Di Costanzo L L Gennadios H A HA Christianson D W DW
Cellular and molecular life sciences : CMLS 20080701 13
Novel structural superfamilies can be identified among the large number of protein structures deposited in the Protein Data Bank based on conservation of fold in addition to conservation of amino acid sequence. Since sequence diverges more rapidly than fold in protein Evolution, proteins with little or no significant sequence identity are occasionally observed to adopt similar folds, thereby reflecting unanticipated evolutionary relationships. Here, we review the unique alpha/beta fold first obs ...[more]
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