Ontology highlight
ABSTRACT:
SUBMITTER: Basto R
PROVIDER: S-EPMC2653712 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Cell 20080601 6
Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic instability and so tumorigenesis. To test this hypothesis, we generated Drosophila lines that have extra centrosomes in approximately 60% of their somatic cells. Many cells with extra centrosomes initially form multipolar spindles, but these spindles ultimately become bipolar. This requires a delay in mitosis that is mediated by the spindle assemb ...[more]