Hexadecameric self-assembled dendrimers built from 2'-deoxyguanosine derivatives.

ABSTRACT: Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed 1,3-dipolar cycloaddition reaction. Discrete SADs are formed with high fidelity and thermal stability even with the increased steric hindrance offered by the dendrons.

SUBMITTER: Betancourt JE 

PROVIDER: S-EPMC2654094 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature