Ontology highlight
ABSTRACT:
SUBMITTER: Pike BL
PROVIDER: S-EPMC2654231 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Pike B L BL Greiner T C TC Wang X X Weisenburger D D DD Hsu Y-H YH Renaud G G Wolfsberg T G TG Kim M M Weisenberger D J DJ Siegmund K D KD Ye W W Groshen S S Mehrian-Shai R R Delabie J J Chan W C WC Laird P W PW Hacia J G JG
Leukemia 20080221 5
In an initial epigenetic characterization of diffuse large B-cell lymphoma (DLBCL), we evaluated the DNA methylation levels of over 500 CpG islands. Twelve CpG islands (AR, CDKN1C, DLC1, DRD2, GATA4, GDNF, GRIN2B, MTHFR, MYOD1, NEUROD1, ONECUT2 and TFAP2A) showed significant methylation in over 85% of tumors. Interestingly, the methylation levels of a CpG island proximal to FLJ21062 differed between the activated B-cell-like (ABC-DLBCL) and germinal center B-cell-like (GCB-DLBCL) subtypes. In ad ...[more]