Ontology highlight
ABSTRACT:
SUBMITTER: Anathy V
PROVIDER: S-EPMC2654302 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Anathy Vikas V Aesif Scott W SW Guala Amy S AS Havermans Marije M Reynaert Niki L NL Ho Ye-Shih YS Budd Ralph C RC Janssen-Heininger Yvonne M W YM
The Journal of cell biology 20090101 2
Reactive oxygen species (ROS) increase ligation of Fas (CD95), a receptor important for regulation of programmed cell death. Glutathionylation of reactive cysteines represents an oxidative modification that can be reversed by glutaredoxins (Grxs). The goal of this study was to determine whether Fas is redox regulated under physiological conditions. In this study, we demonstrate that stimulation with Fas ligand (FasL) induces S-glutathionylation of Fas at cysteine 294 independently of nicotinamid ...[more]