Ontology highlight
ABSTRACT:
SUBMITTER: Griffin HR
PROVIDER: S-EPMC2654913 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Griffin Helen R HR Hall Darroch H DH Topf Ana A Eden James J Stuart A Graham AG Parsons Jonathan J Peart Ian I Deanfield John E JE O'Sullivan John J Babu-Narayan Sonya V SV Gatzoulis Michael A MA Bu'lock Frances A FA Bhattacharya Shoumo S Bentham Jamie J Farrall Martin M Granados Riveron Javier J Brook J David JD Burn John J Cordell Heather J HJ Goodship Judith A JA Keavney Bernard B
PloS one 20090324 3
Several previous studies have investigated the role of common promoter variants in the vascular endothelial growth factor (VEGF) gene in causing congenital cardiovascular malformation (CVM). However, results have been discrepant between studies and no study to date has comprehensively characterised variation throughout the gene. We genotyped 771 CVM cases, of whom 595 had the outflow tract malformation Tetralogy of Fallot (TOF), and carried out TDT and case-control analyses using haplotype-taggi ...[more]