Ontology highlight
ABSTRACT:
SUBMITTER: Wright PK
PROVIDER: S-EPMC2655148 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Wright Paul K PK May Felicity Eb FE Darby Steve S Saif Rehan R Lennard Tom Wj TW Westley Bruce R BR
International journal of clinical and experimental pathology 20090130 5
Estrogens are critical mediators of breast tumorigenesis. This occurs via the action of estrogens on the estrogen receptor (ER), which regulates the transcriptome of breast cancer cells. Despite the long history of the search for estrogen-regulated genes in breast cancer, knowledge of the E2-regulated transcriptome and its effects is incomplete. We used Affymetrix GeneChips to profile the effects of estradiol on the expression of genes in EFF-3, EFM-19 and MCF-7 cells. In addition to many well-c ...[more]