Ontology highlight
ABSTRACT:
SUBMITTER: McNicoll CF
PROVIDER: S-EPMC2655323 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Movement disorders : official journal of the Movement Disorder Society 20080801 11
The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping ...[more]