Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
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ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC2655452 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
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Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
Chen Shi S Mao Xiangzhao X Shen Yaling Y Zhou Yongjun Y Li Jialiang J Wang Lianrong L Tao Xinyi X Yang Liang L Wang Yuxiao Y Zhou Xiufen X Deng Zixin Z Wei Dongzhi D
Applied and environmental microbiology 20090109 6
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin. ...[more]
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