Ontology highlight
ABSTRACT:
SUBMITTER: Brazdova M
PROVIDER: S-EPMC2655687 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Brázdová Marie M Quante Timo T Tögel Lars L Walter Korden K Loscher Christine C Tichý Vlastimil V Cincárová Lenka L Deppert Wolfgang W Tolstonog Genrich V GV
Nucleic acids research 20090112 5
Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. To identify functional binding sites of mutp53, we established a small library of genomic sequences bound by p53(R273H) in U251 human glioblastoma cells using chromatin ...[more]