Ontology highlight
ABSTRACT:
SUBMITTER: Parish IA
PROVIDER: S-EPMC2656177 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Parish Ian A IA Waithman Jason J Davey Gayle M GM Belz Gabrielle T GT Mintern Justine D JD Kurts Christian C Sutherland Robyn M RM Carbone Francis R FR Heath William R WR
Proceedings of the National Academy of Sciences of the United States of America 20090220 10
Autoimmune diseases tend to be chronic and progressive, but how these responses are sustained is not clear. One cell type that might contribute to autoimmunity is the cytotoxic T lymphocyte (CTL), which, as a consequence of causing tissue destruction and production of cytokines, could provide a sustained supply of antigen and inflammatory signals for dendritic cells to maintain immune stimulation. Here we examined whether such CTL-mediated tissue damage alone could provide antigen in the right c ...[more]