Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC2656179 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Yang Jiang J Bielenberg Diane R DR Rodig Scott J SJ Doiron Robert R Clifton Matthew C MC Kung Andrew L AL Strong Roland K RK Zurakowski David D Moses Marsha A MA
Proceedings of the National Academy of Sciences of the United States of America 20090223 10
Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, and we identify the mechanisms underlying this function. We first found that Lcn2 levels were consistently associated with invasive breast cancer in human tissue and urine samples. To investigate the function of Lcn2 in breast cancer progression, Lcn2 was overexpressed in human breast cancer cells and was found to up-regulate mesenchymal markers, including vimentin and fibronectin, down-regulate the epithelial marker E-c ...[more]