Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits.

ABSTRACT:

Introduction

Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis, an experimental model of rheumatoid arthritis.

Methods

Following the induction of arthritis in both knee joints by ovalbumin injection into the joint spaces of pre-immunized rabbits, increasing daily doses of adrenomedullin were injected into the knee joint spaces or saline was injected into the contralateral knee joint spaces as the control. For time-course experiments, adrenomedullin and saline were injected into the knee joint spaces daily for 7 days and 20 days. The degr

SUBMITTER: Okura T 

PROVIDER: S-EPMC2656235 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature