Ontology highlight
ABSTRACT:
SUBMITTER: Faber J
PROVIDER: S-EPMC2656267 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Faber Joerg J Krivtsov Andrei V AV Stubbs Matthew C MC Wright Renee R Davis Tina N TN van den Heuvel-Eibrink Marry M Zwaan Christian M CM Kung Andrew L AL Armstrong Scott A SA
Blood 20081203 11
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select Homeobox genes, including HOXA9. Here, we investigated the effects of HOXA9 suppression in MLL-rearranged and MLL-germline leukemias using RNA interference. Gene expression profiling after HOXA9 suppre ...[more]