Ontology highlight
ABSTRACT:
SUBMITTER: Louis CU
PROVIDER: S-EPMC2656271 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Louis Chrystal U CU Straathof Karin K Bollard Catherine M CM Gerken Claudia C Huls M Helen MH Gresik M Victoria MV Wu Meng-Fen MF Weiss Heidi L HL Gee Adrian P AP Brenner Malcolm K MK Rooney Cliona M CM Heslop Helen E HE Gottschalk Stephen S
Blood 20081029 11
Treatment of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) with EBV-specific cytotoxic T cells (EBV-specific CTL) has been promising, producing clinical responses. However, infused EBV-specific CTL did not expand in vivo, likely limiting their antitumor activity. Lymphodepleting patients with chemotherapy before T-cell transfer enhances in vivo T-cell expansion, but results in nonspecific destruction of the resident immune system and can have significant toxicity. To evaluate ...[more]