Ontology highlight
ABSTRACT:
SUBMITTER: Frank MJ
PROVIDER: S-EPMC2656273 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Frank Matthew J MJ Dawson David W DW Bensinger Steven J SJ Hong Jason S JS Knosp Wendy M WM Xu Lizhong L Balatoni Cynthia E CE Allen Eric L EL Shen Rhine R RR Bar-Sagi Dafna D Martin Gail R GR Teitell Michael A MA
Blood 20090115 11
B-cell lymphoma is the most common immune system malignancy. TCL1 transgenic mice (TCL1-tg), in which TCL1 is ectopically expressed in mature lymphocytes, develop multiple B- and T-cell leukemia and lymphoma subtypes, supporting an oncogenic role for TCL1 that probably involves AKT and MAPK-ERK signaling pathway augmentation. Additional, largely unknown genetic and epigenetic alterations cooperate with TCL1 during lymphoma progression. We examined DNA methylation patterns in TCL1-tg B-cell tumor ...[more]