The role of mPer1 in morphine dependence in mice.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2656444 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
The role of mPer1 in morphine dependence in mice.
Liu Y Y Wang Y Y Wan C C Zhou W W Peng T T Liu Y Y Wang Z Z Li G G Cornelisson G G Halberg F F
Neuroscience 20050101 2
Investigations using Drosophila melanogaster have shown that the circadian clock gene period can influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate cocaine sensitization and reward. In the present study, we applied DNAzyme targeting mPer1 to interfere the expression of mPer1 in CNS in mice and studied the role of mPer1 on morphine dependence. We found that the DNAzyme could attenuate the expression of mPer1 in CNS in mice. Mice treated with DNAzyme and ...[more]
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