Correlation signature of the macroscopic states of the gene regulatory network in cancer.
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ABSTRACT:
SUBMITTER: Slavov N
PROVIDER: S-EPMC2657377 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Correlation signature of the macroscopic states of the gene regulatory network in cancer.
Slavov Nikolai N Dawson Kenneth A KA
Proceedings of the National Academy of Sciences of the United States of America 20090225 11
Although cancer types differ substantially, many cancers share common gene expression signatures. Consistent with this observation, we find convergent and representative distributions and correlation vectors that are distinct in cancer and noncancer ensembles. These differences originate in many genes, but comparatively few genes account for the major differences. We identify genes with different combinatorial regulation in cancer and noncancer as indicated by significant differences in their co ...[more]
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